Differing Effect of Protein Isolates from Different Cultivars of Blue Lupin on Plasma Lipoproteins of Hypercholesterolemic RatsThe research was supported by a grant from the Bundesministerium fr Wirtschaft und Technologie (BMWi)

نویسندگان

  • Anja BETTZIECHE
  • Corinna BRANDSCH
  • Manja SCHMIDT
  • Kristin WEIßE
  • Klaus EDER
  • Gabriele I. STANGL
چکیده

Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and -/ conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and -/ conglutin had lower triglyceride concentrations in the plasma ( 24% and 21%, respectively) and very-lowdensity lipoprotein (VLDL; 40% and 29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol ( 37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Study of steroidal compounds from peel and seed of some pomegranate cultivars (Punica granatum L.) and investigating the effect of pomegranate seed oil on blood lipid levels in hypercholesterolemic rabbits

Background: High level of blood cholesterol can cause diseases such as atherosclerosis, high blood pressure, cardiovascular diseases, and increase the chance of apoplexy and fatty liver. Unsaturated fatty acids play important roles in preventing cardiovascular diseases because they decrease total cholesterols and LDL-C in the blood. Objective: The study investigates some sterol compounds of Ira...

متن کامل

Evaluation of agronomic traits and seed yield of lupin (Lupinus spp. L.) germplasm under environmental conditions of Karaj in Iran

Introduction of new crops is one of the strategic approaches for production of feed for livestock and hence protein requirements for the increasing population. White lupine (Lupinus albus L.), yellow lupine (L. luteus L.) and blue (narrow leaf) lupine (L. angustifolius L.) are legumes that can be used for production of feed for livestock and as result protein requirements for the increasing pop...

متن کامل

Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats

Increased plasma cholesterol is known to be a major risk related to the development of coronary artery disease. The main purpose of this study was to determine possible effects of the ethanolic extract of aerial parts of Peucedanum pastinacifolium on the serum lipids in hypercholesterolemic rats. Experimental hypercholesterolemia was induced by feeding rats ???? ????????????????????????????...

متن کامل

Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats

Increased plasma cholesterol is known to be a major risk related to the development of coronary artery disease. The main purpose of this study was to determine possible effects of the ethanolic extract of aerial parts of Peucedanum pastinacifolium on the serum lipids in hypercholesterolemic rats. Experimental hypercholesterolemia was induced by feeding rats ???? ????????????????????????????...

متن کامل

Anti-hypercholesterolemic Effect of Berbamine Isolated from Rhizoma Coptidis in Hypercholesterolemic Zebrafish Induced by High-Cholesterol Diet

The anti-hypercholesterolemic effect of berbamine (BBM) isolated from Rhizoma Coptidis (RC) was investigated in hypercholesterolemic zebrafish model induced by high-cholesterol (HC) diet. Zebrafish embryo assay revealed no significant difference in morphology and cell death with the treatment of BBM less than 20 μg/mL. In zebrafish larvae, the fluorescently labeled cholesterol in caudal artery ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008